Junior Medical Scientist
Company: Case Western Reserve University
Location: Cuyahoga Falls
Posted on: January 23, 2023
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Job Description:
Job Description
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POSITION OBJECTIVE
Working under general supervision, the Research Assistant 2 will
plan and carry out research projects in accordance with general
plans focused on understanding how genetic variation and
environmental exposure (gut-brain-axis) predispose to
neurodegenerative disorders including Frontotemporal dementia
(FTD), Amyotrophic lateral sclerosis (ALS) and Alzheimer's disease
(AD). This individual will perform technical procedures and
experiments according to specific instructions/protocols including
flow cytometry, immunoblot, ELISA, qRT-PCR, and microscopy
collected with aid by supervising staff. Data will be collected and
recorded in laboratory computers for statistical analyses and the
research assistant will contribute to the generation of data
figures for grant submissions and publication of manuscripts, as
well as present data at group meetings. -This individual will
pro-actively follow their job duties while adhering to and ensuring
ethical compliance with all legal regulations. They will also
ensure strict adherence to all safety guidelines while dealing with
hazardous substances, animal subject- and human subject-derived
materials in the lab and will have the physical stamina and
endurance to perform all associated tasks. This position will work
with animals.
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ESSENTIAL FUNCTIONS
Plan and carry out research assignments in accordance with general
plans. Experiments may include tissue culture, common molecular
biology techniques and in vivo studies using mice such as (1)
isolation and processing of cells derived from mouse nervous
tissues and immune tissues for histology, immunofluorescence,
imaging and flow cytometry, (2) ex vivo culture of bone marrow
derived macrophages for stimulations and quantitative analysis of
protein, RNA, cellular composition and morphology and (3) in vitro
culture of human induced pluripotent stem cells with directed
differentiation into motor neurons and microglia using
viral-mediated transcription factor expression and small molecule
patterning, co-culture and electrophysiological assessment using
multi-electrode arrays and optopatch. (40%) Collect and analyze
data. Provide data in a presentable format for use by the principle
investigator and other lab members as they generate annual reports
for granting agencies, manuscripts, and grant and pilot
applications. Manage individual experiments, reporting these in a
consistent fashion and in a timely manner, managing issues of the
scientific method including positive and negative controls. (20%)
Perform duties concerning rodent animal husbandry. Manage mouse
cohorts through health monitoring, breeding, tagging, and
genotyping. (15%) Perform general laboratory support tasks
including ordering and stocking communal reagents and supplies,
organizing lab spaces, and receiving deliveries. Install, maintain
and repair complex equipment. (10%) Perform regular quality
controls of cell lines including genotyping and mycobacterium
testing. (10%)
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NONESSENTIAL FUNCTIONS
Perform other duties as assigned (5%)
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CONTACTS
Department: Daily contact with supervisor to discuss research and
maintain workflow
University: Occasional contact with other departments to share
information and help enable collaborations. Limited interaction
with regulatory components (IACUC, IBC, IRB)
External: Occasional contact with vendors to procure supplies
Students: Occasional contact with student employees to explain
policies and procedures and ensure proper adherence to all legal,
health and safety standards
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SUPERVISORY RESPONSIBILITY
This position has no direct supervision of staff employees.
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QUALIFICATIONS
Experience: Bachelor's degree in science and 1 to 3 years of
related experience or Associate's degree in an approved
biotechnology program and 2 to 4 years of experience.
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REQUIRED SKILLS -
Has knowledge of commonly-used concepts, practices, and procedures
within a particular field including strong molecular biology skills
(PCR, western blots, retrovirial/lentiviral constructs). Prior
experience working with animals is required Relies on instructions
and pre-established guidelines to perform the functions of the job
Ability to operate lab equipment Ability to meet consistent
attendance Ability to interact with colleagues and supervisors
face-to-face Strong organizational skills and good habit of
maintaining a clean lab working environment; demonstrates attention
to detail and accuracy, time management skills and proven ability
to follow through on assigned projects Must be highly motivated,
responsible, dependable, ethical and a self-starter. Ability to
work with sensitive information and maintain confidentiality.
Proficiency in general computer programs. Microsoft Office and
Graphpad Prism is preferred. Adobe Photoshop, Illustrator, Zen and
Flowjo is a plus. Must have the ability to maintain meticulous,
complete and easily retrievable laboratory data. Must have the
ability to willingly learn new techniques and procedures as needed,
follow established protocols or laboratory procedures and request
clarification if necessary. Must demonstrate compliance with
University animal research and care (ARC) policies and procedures
and compliance to regulations of the Animal Welfare Act, Public
Health Service Policy, AAALAC guidelines and other applicable
regulatory guidelines. Must demonstrate compassion for animals
within University facilities and dedication to the Animal Resource
Center's mission. Must handle animals with care and respect at all
times. Must be able and willing to learn new techniques,
procedures, and computer gear to protect the health of the
animals.
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WORKING CONDITIONS
General laboratory environment. The employee is required to work
with and handle research animals and may have exposure to hazards.
The employee will need to wear appropriate protective equipment
such as gloves, sleeves and lab coat. Working conditions will
require working at the bench and tissue culture hood in a molecular
genetics/neuroinflammation laboratory, working with mice in the
laboratory and in the animal facility, and when needed working
outside standard working days or hours as required by the needs of
a given experiment.
Case Western Reserve University's animal facilities are accredited
by the Association for the Assessment and Accreditation of
Laboratory Animal Care (AAALAC) and is managed according to the
"Guide for the Care and Use of Laboratory Animals" appropriate
Federal Animal Welfare Regulations, and the Public Health Service
"Policy on the Humane Care and Use of Laboratory Animals." This
position, and all animal research personnel, are subject to
internal compliance to SOM Animal Resource Center Standard
Operating Procedures and to compliance regulations of the Animal
Welfare Act, Public Health Service Policy, AAALAC guidelines, the
State of Ohio Veterinary Practice Act, Federal Drug Enforcement
Administration regulatory guidelines, US Food and Drug
Administration Center for Veterinary Medicine regulations and other
applicable regulatory guidelines.
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Diversity Statement
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In employment, as in education, Case Western Reserve University is
committed to Equal Opportunity and Diversity. - Women, veterans,
members of underrepresented minority groups, and individuals with
disabilities are encouraged to apply.
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Reasonable Accommodations
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Case Western Reserve University provides reasonable accommodations
to applicants with disabilities. - Applicants requiring a
reasonable accommodation for any part of the application and hiring
process should contact the Office of Equity -at 216-368-3066 -to
request a reasonable accommodation. - Determinations as to granting
reasonable accommodations for any applicant will be made on a
case-by-case basis.
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COVID Vaccination
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Case Western Reserve University has implemented a COVID Vaccination
policy requiring evidence of COVID-19 vaccination for all students,
faculty and staff with an on-campus presence. Religious and medical
exemptions may be provided in accordance with applicable federal
and state laws. For more information go to:
https://case.edu/equity/covid-19-accommodations. Applicants may
contact the Office of Equity at 216-368-3066 /equity@case.edu for
information regarding religious or medical exemptions as an
accommodation.
Keywords: Case Western Reserve University, Cuyahoga Falls , Junior Medical Scientist, Healthcare , Cuyahoga Falls, Ohio
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